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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Bevacizumab

3

XII.a Left or biventricular dysfunction/failure

1
Last update : 14/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pazopanib
2
Sorafenib
2
Sunitinib
2

Publications

Bevacizumab: A Rare Cause of Nonischemic Cardiomyopathy.
Case reports in cardiology 2018;2018;1361326 2018
Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.
Journal of thoracic disease 2016 Sep;8;2646-2650 2016 Sep
Cardiotoxicity in patients treated with bevacizumab is potentially reversible.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Jun 20;29;e560-2 2011 Jun 20

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