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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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  • Drugs
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TNF-alpha antagonists / inhibitors

5

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

3
Last update : 14/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Safety of infliximab in Crohn's disease: a large single-center experience.
Inflammatory bowel diseases 2010 Dec;16;2109-16 2010 Dec
Are biologics safe in the treatment of atopic dermatitis? A review with a focus on immediate hypersensitivity reactions.
Journal of the American Academy of Dermatology 2009 Oct;61;666-76 2009 Oct
Correlation between atopy and hypersensitivity reactions during therapy with three different TNF-alpha blocking agents in rheumatoid arthritis.
Clinical and experimental rheumatology 2009;27;333-6 2009
Clinical immunotoxicity of therapeutic proteins.
Expert opinion on drug metabolism & toxicology 2008 Dec;4;1537-49 2008 Dec
The incidence and management of infusion reactions to infliximab: a large center experience.
The American journal of gastroenterology 2003 Jun;98;1315-24 2003 Jun

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