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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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TNF-alpha antagonists / inhibitors

5

XVII.n Legionella pneumophila pneumonia

2
Last update : 10/09/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adalimumab
3
Etanercept
4
Golimumab
1
Infliximab
5

Publications

Incidence and risk factors of Legionella pneumophila pneumonia during anti-tumor necrosis factor therapy: a prospective French study.
Chest 2013 Sep;144;990-998 2013 Sep
Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2012 Dec;18;793-806 2012 Dec
Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective.
Current rheumatology reviews 2011 Feb;7;77-87 2011 Feb
Clinical and radiological features of acute-onset diffuse interstitial lung diseases in patients with rheumatoid arthritis receiving treatment with biological agents: importance of Pneumocystis pneumonia in Japan revealed by a multicenter study.
Internal medicine (Tokyo, Japan) 2011;50;305-13 2011
Legionella pneumophila pneumonia in a pregnant woman treated with anti-TNF-α antibodies for Crohn's disease: a case report.
Journal of Crohn's & colitis 2010 Dec;4;687-9 2010 Dec
Severe Legionella pneumophila pneumonia following infliximab therapy in a patient with Crohn's disease.
Inflammatory bowel diseases 2009 Aug;15;1240-4 2009 Aug

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