Pneumotox » Drug » Sildenafil » III.a - Alveolar hemorrhage (AH), diffuse AH (DAH)

Sildenafil

It can be difficult to determine whether DAH is present in patients with hemoptysis and concomitant pulmonary infiltrates. E.g. PMID 23544289

Last update : 12/10/2013

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment