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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Oxycodone

3

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

1
Last update : 07/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Massive OxyContin ingestion refractory to naloxone therapy.
Annals of emergency medicine 2002 Oct;40;425-8 2002 Oct
Time course of changes in breathing pattern in morphine- and oxycodone-induced respiratory depression.
Anaesthesia 1999 Sep;54;835-40 1999 Sep

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