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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alemtuzumab

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Alemtuzumab-induced lung injury in multiple sclerosis: Learning from adversity in three patients.
Multiple sclerosis and related disorders 2020 Jan;37;101450 2020 Jan
Diffuse alveolar hemorrhage during alemtuzumab infusion in a patient with multiple sclerosis: a case report.
BMC pharmacology & toxicology 2018 Nov 19;19;75 2018 Nov 19
Diffuse Alveolar haemorrhage: a fatal complication after alemtuzumab induction therapy in renal transplantation.
Transplantation proceedings 2015;47;151-4 2015
Diffuse alveolar hemorrhage following alemtuzumab.
Chest 2008 Jun;133;1476-1478 2008 Jun

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