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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Surfactant

1

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 11/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Severe airway obstruction during surfactant administration using a standardized protocol: a prospective, observational study.
Journal of perinatology : official journal of the California Perinatal Association 2012 Apr;32;270-5 2012 Apr

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