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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (medium term & late effects)

5

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

3
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy to the breast
4
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5

Publications

A case of refractory bilateral pleural effusion due to post-irradiation constrictive pericarditis.
Respirology (Carlton, Vic.) 2002 Dec;7;365-8 2002 Dec
Bilateral pleural effusion due to mediastinal fibrosis induced by radiotherapy.
Chest 1993 Oct;104;1276-8 1993 Oct
Recurrent massive pleural effusion as a late complication of radiotherapy in Hodgkin's disease.
Chest 1991 Oct;100;1165-6 1991 Oct
Radiation-related pericardial effusions in patients with Hodgkin's disease.
Medicine 1975 May;54;245-59 1975 May

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