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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy (medium term & late effects)

5

XII.o Coronary artery disease (subacute, chronic)

2

Review at 24092234

Last update : 03/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
5
Radiation therapy to the breast
4
Radiation therapy to the chest
5
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
2
Radiation therapy, mantle-field-
5
Radiation therapy, stereotactic (SBRT)
5

Publications

How to prevent and manage radiation-induced coronary artery disease.
Heart (British Cardiac Society) 2018 Oct;104;1647-1653 2018 Oct
Pulmonary fibrosis on multidetector computed tomography and mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery.
The Journal of thoracic and cardiovascular surgery 2014 Aug;148;475-81.e3 2014 Aug
10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model.
International journal of radiation biology 2009 Dec;85;1089-100 2009 Dec
Severe infundibular pulmonary stenosis and coronary artery stenosis with ventricular tachycardia 24 years after mediastinal irradiation.
Internal medicine (Tokyo, Japan) 2005 Sep;44;963-6 2005 Sep
Symptomatic coronary artery disease after mantle irradiation for Hodgkin's disease.
International journal of radiation oncology, biology, physics 1996 Nov 01;36;881-9 1996 Nov 01

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