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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ipilimumab

4

X.am Immune-related adverse effect/toxicity

3
Last update : 27/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
CTLA4 blocking immunotherapy
3
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Tremelimumab
1

Publications

Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication.
Case reports in oncological medicine 2015;2015;794842 2015
A severe case of ipilimumab-induced guillain-barré syndrome revealed by an occlusive enteric neuropathy: a differential diagnosis for ipilimumab-induced colitis.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2013 Jan;36;77-8 2013 Jan
Immune toxicities and long remission duration after ipilimumab therapy for metastatic melanoma: two illustrative cases.
Current oncology (Toronto, Ont.) 2013 Apr;20;e165-9 2013 Apr
Burst kinetics of sodium channels which lack fast inactivation in mouse neuroblastoma cells.
The Journal of physiology 1987 Nov;392;563-85 1987 Nov

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