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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carbamazepine

3

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 10/07/2012
 
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Diagnosing DIRD
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Anticonvulsants
3

Publications

Bronchiolitis obliterans and organising pneumonia caused by carbamazepine and mimicking community acquired pneumonia.
Postgraduate medical journal 2002 Oct;78;621-2 2002 Oct
Cyclophosphamide in severe steroid-resistant bronchiolitis obliterans organizing pneumonia.
Respiratory medicine 1997 Mar;91;175-7 1997 Mar
Bronchiolitis obliterans with organizing pneumonia and cold agglutinin disease associated with phenytoin hypersensitivity syndrome.
Chest 1997 Dec;112;1697-9 1997 Dec
Lupus and pulmonary nodules consistent with bronchiolitis obliterans organizing pneumonia induced by carbamazepine.
Mayo Clinic proceedings 1997 Dec;72;1145-7 1997 Dec

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