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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Allergen immunotherapy

3

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 05/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Anaphylaxis: still a ghost behind allergen immunotherapy.
Current opinion in allergy and clinical immunology 2014 Aug;14;316-22 2014 Aug
Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.
Allergy 2013 Jul;68;929-37 2013 Jul
Allergen immunotherapy in allergic respiratory diseases: from mechanisms to meta-analyses.
Chest 2012 May;141;1303-1314 2012 May
Survey of fatalities from skin testing and immunotherapy 1985-1989.
The Journal of allergy and clinical immunology 1993 Jul;92;6-15 1993 Jul

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