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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Benzodiazepines

5

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

2
Last update : 08/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Ethanol (ethyl alcohol, 'alcohol')
5
Midazolam
1

Publications

The Use of Benzodiazepine Receptor Agonists and Risk of Respiratory Failure in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Case-Control Study.
Sleep 2015 Jul 01;38;1045-50 2015 Jul 01
Respiratory acidosis secondary to drug therapy.
Archivos de bronconeumologia 2015 Apr;51;204-5 2015 Apr
Comparison of toxicity associated with nonmedical use of benzodiazepines with buprenorphine or methadone.
Drug and alcohol dependence 2014 May 01;138;118-23 2014 May 01
Urine specimen detection of concurrent nonprescribed medicinal and illicit drug use in patients prescribed buprenorphine.
Journal of analytical toxicology 2013;37;636-41 2013
Fentanyl use, misuse, and abuse: a summary of 23 postmortem cases.
Journal of analytical toxicology 2003 Oct;27;499-504 2003 Oct
Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines.
Journal of toxicology. Clinical toxicology 2002;40;35-47 2002

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