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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Excipients-Vehicle-Preservatives (of drugs)
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Anaphylaxis-Anaphylactoid reaction (can be fatal)
1
Last update :
19/04/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Amiodarone
Benzylbenzoate
Cremophor
Crospovidone
Preservatives
Ricin (Castor oil)
Sesame oil
Soybean
Talc (inhaled, sniffed, i.v., intrapleural)
Publications
Hypersensitivity to methylprednisolone sodium succinate in children with milk allergy.
Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient.
A case of propofol-induced oropharyngeal angioedema and bronchospasm.