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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Excipients-Vehicle-Preservatives (of drugs)

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 19/04/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
5
Benzylbenzoate
1
Cremophor
1
Crospovidone
2
Preservatives
2
Ricin (Castor oil)
2
Sesame oil
1
Soybean
1
Talc (inhaled, sniffed, i.v., intrapleural)
3

Publications

Hypersensitivity to methylprednisolone sodium succinate in children with milk allergy.
The journal of allergy and clinical immunology. In practice 2014;2;471-4 2014
Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient.
Forensic science international 2013 May 10;228;e28-32 2013 May 10
A case of propofol-induced oropharyngeal angioedema and bronchospasm.
Allergy, asthma & immunology research 2012 Jan;4;46-8 2012 Jan

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