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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Proton pump inhibitors (PPI)

2

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 03/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Lessons from two cases of anaphylaxis to proton pump inhibitors.
Journal of clinical pharmacy and therapeutics 2012 Oct;37;614-6 2012 Oct
Hypersensitivity reactions to proton pump inhibitors.
Current opinion in allergy and clinical immunology 2012 Aug;12;348-53 2012 Aug

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