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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carmustine (BCNU)

3

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 11/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bendamustine
1
Fotemustine
1
Lomustine (CCNU)
3
Nitrosoureas (suffixes '-NU', '-mustine')
4

Publications

BCNU (Bis-chloroethylnitrosourea, Carmustine) Toxicity Presented as a Large Pleural Effusion 60 Days Post Autologous Stem Cell Transplant for Non-Hodgkin Lymphoma.
Cureus 2019 Feb 12;11;e4052 2019 Feb 12
BCNU toxicity presenting with a large pericardial and pleural effusion.
Annals of transplantation 2008;13;44-7 2008

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