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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Carmustine (BCNU)
3
V.f
Pneumothorax
1
Last update :
11/07/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Bendamustine
Fotemustine
Lomustine (CCNU)
Nitrosoureas (suffixes '-NU', '-mustine')
Publications
Active lung fibrosis up to 17 years after chemotherapy with carmustine (BCNU) in childhood.
Fatal pneumothorax in "BCNU lung".