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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydroxychloroquine

3

XII.p QTc prolongation

1
Last update : 01/04/2020
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Chloroquine
3
Malaria prophylaxis
2
Mefloquine
1

Publications

Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: A Meta-analysis.
International journal of antimicrobial agents 2020 Dec;56;106212 2020 Dec
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.
JAMA network open 2020 Apr 24;3;e208857 2020 Apr 24
[Hazard of acquired long QT syndrome during coronavirus pandemic. Focus on hydroxychloroquine].
Orvosi hetilap 2020 Apr 01;161;689-691 2020 Apr 01
Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine.
Case reports in cardiology 2016;2016;4626279 2016

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