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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, inhaled (ICS)

5

XVII.b Opportunistic pulmonary/systemic infections

2
Last update : 31/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Beclomethasone
2
Budesonide (inhaled)
3
Corticosteroids, systemic (oral, parenteral)
5
Fluticasone (inhaled - ICS)
4

Publications

Laryngeal aspergilloma: a complication of inhaled fluticasone therapy for asthma.
Respirology case reports 2014 Dec;2;123-5 2014 Dec
[Risk of pneumonia with inhaled corticosteroids for stable chronic obstructive pulmonary disease patients].
Medicina clinica 2011 Sep 17;137;302-4 2011 Sep 17
Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results.
The European respiratory journal 2009 Sep;34;641-7 2009 Sep
Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.
JAMA 2008 Nov 26;300;2407-16 2008 Nov 26
Invasive pulmonary filamentous fungal infection in a patient receiving inhaled corticosteroid therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002 Sep 01;35;e54-6 2002 Sep 01
Invasive pulmonary aspergillosis associated with high-dose inhaled fluticasone.
The New England journal of medicine 2000 Aug 24;343;586 2000 Aug 24

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