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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Erythropoietin (EPO)

2

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

2
Last update : 17/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Occurrence of acute pulmonary embolism induced by recombinant erythropoietin during treatment of pure red cell aplasia associated with thymoma: A case report.
Medicine 2019 Mar;98;e14789 2019 Mar
Patterns of use and risks associated with erythropoiesis-stimulating agents among Medicare patients with cancer.
Journal of the National Cancer Institute 2009 Dec 02;101;1633-41 2009 Dec 02
Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia.
JAMA 2008 Feb 27;299;914-24 2008 Feb 27

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