Pneumotox » Drug » Antiplatelet agents: Glycoprotein IIb/IIIa inhibitors » III.a - Alveolar hemorrhage (AH), diffuse AH (DAH)

Antiplatelet agents: Glycoprotein IIb/IIIa inhibitors

DAH and other bleeding incidents fro this class of medications can occur with or without concomitant thrombocytopenia (PMID 22767141)

Last update : 15/06/2013

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment