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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Forceful inspiration against a closed glottis or airway

4

III.f Negative pressure pulmonary hemorrhage (NPPH)

1
Last update : 28/01/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Diffuse Alveolar Hemorrhage After Orotracheal Extubation Probably Induced by Sevoflurane Inhalation.
Archivos de bronconeumologia 2021 Jan 28;; 2021 Jan 28
Delayed presentation: negative pressure pulmonary hemorrhage.
Journal of clinical anesthesia 2012 Sep;24;490-3 2012 Sep
Negative pressure post-tracheal extubation alveolar hemorrhage.
Anesthesia and analgesia 2001 Jan;92;273-5 2001 Jan

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