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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Radiation therapy, mantle-field-

5

IX.j Phrenic nerve injury - Hemi- or bilateral diaphragmatic paralysis

1
Last update : 29/10/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Radiation therapy (early effects)
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Radiation therapy (medium term & late effects)
5

Publications

Bilateral phrenic nerve dysfunction: a late complication of mantle radiation.
Journal of neuro-oncology 2011 Jun;103;393-5 2011 Jun

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