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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Clozapine

3

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

2
Last update : 31/08/2013
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Antidepressants
3

Publications

Clozapine-induced peripheral and pleural fluid eosinophilia.
The Annals of pharmacotherapy 2012 Feb;46;e4 2012 Feb
Papular rash and bilateral pleural effusion associated with clozapine.
The Annals of pharmacotherapy 1999 Sep;33;1008-9 1999 Sep
Comment: papular rash and bilateral pleural effusion associated with clozapine.
The Annals of pharmacotherapy 1999 Dec;33;1374 1999 Dec

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