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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Neuromuscular blocking agents (NMBA-NMBD)

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

3
Last update : 29/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Cisatracurium
1
Curares
5
Rocuronium
1
Vecuronium
2

Publications

Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2024 Jan;54;11-20 2024 Jan
Anaphylactic bronchospasm during general anesthesia is not related to asthma.
Allergy 2015 Apr;70;453-6 2015 Apr
Multiple cross-reactivity to several types of neuromuscular blocking agents in a patient with rocuronium anaphylaxis.
Korean journal of anesthesiology 2013 Nov;65;473-4 2013 Nov
Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.
Allergy 2013 Jul;68;929-37 2013 Jul
Muscle relaxants allergy.
International journal of immunopathology and pharmacology 2011;24;S35-46 2011
Rocuronium bromide induced anaphylaxis in a child -A case report-.
Korean journal of anesthesiology 2010 Dec;59;411-5 2010 Dec
The clinical spectrum of anaphylaxis in north-west England.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996 Dec;26;1364-70 1996 Dec
Muscle relaxants and histamine release.
Acta anaesthesiologica Scandinavica. Supplementum 1995;106;7-12 1995
Allergic reactions during anesthesia.
Anesthesia and analgesia 1983 Mar;62;341-56 1983 Mar

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