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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cytosine arabinoside - Aracytine - Cytarabine - Ara-C

3

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 15/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Diffuse Alveolar Hemorrhage in the Setting of Cytarabine Therapy in a Critically Ill Patient.
Cureus 2021 Nov;13;e19575 2021 Nov
Pulmonary drug toxicity: radiologic and pathologic manifestations.
Radiographics : a review publication of the Radiological Society of North America, Inc 2000;20;1245-59 2000

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