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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cytosine arabinoside - Aracytine - Cytarabine - Ara-C

3

XVI.v Imaging: Centrilobular micronodules (can be diffuse)

1
Last update : 19/05/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Centrilobular ground-glass nodule pattern in acute myeloid leukemia patients receiving cytosine arabinoside chemotherapy: an important form of drug-induced lung disease.
Diagnostic and interventional radiology (Ankara, Turkey) 2024 Jan 08;30;28-29 2024 Jan 08
A new pattern of cytosine-arabinoside-induced lung toxicity.
British journal of haematology 2009 Dec;147;771-4 2009 Dec

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