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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pregabalin

1

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

1
Last update : 14/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Risk to heroin users of polydrug use of pregabalin or gabapentin.
Addiction (Abingdon, England) 2017 Sep;112;1580-1589 2017 Sep
Significant pregabalin toxicity managed with supportive care alone.
Journal of medical toxicology : official journal of the American College of Medical Toxicology 2010 Dec;6;435-7 2010 Dec

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