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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dantrolene

2

V.b Eosinophilic pleural effusion

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Iatrogenic eosinophilic pleural effusion.
European respiratory review : an official journal of the European Respiratory Society 2011 Jun;20;118-20 2011 Jun
Dantrolene and pleural effusion: case report and review of literature.
Spinal cord 2004 May;42;317-20 2004 May
Eosinophilic pleural effusion due to dantrolene: resolution with steroid therapy.
Southern medical journal 2001 May;94;502-4 2001 May
[Dantrolene-induced pleurisy: a case report].
Revue de pneumologie clinique 2000 Sep;56;261-3 2000 Sep
Pleural effusion associated with chronic dantrolene administration.
The Annals of pharmacotherapy 1994 May;28;587-9 1994 May
Pneumonitis, pleural effusion and pericarditis following treatment with dantrolene.
Journal of neurology, neurosurgery, and psychiatry 1984 May;47;553-4 1984 May
Pleuropericardial reaction to treatment with dantrolene.
JAMA 1979 Dec 21;242;2772-4 1979 Dec 21

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