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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)
4
X.k
Sarcoid-like granulomatosis (endo-/extrathoracic)
1
Last update :
13/01/2016
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Silicone, fluid
Publications
Siliconosis: autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses.
Remission of sarcoidosis following removal of silicone gel breast implants.