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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dinitrophenol (2, 4-dinitrophenol or DNP)

3

XII.m Cardiac- cardiorespiratory/pulmonary arrest

2
Last update : 23/05/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aspirin (Salicylate-ASA) - Aspirin containing drugs
5
Weight loss-, slimming agents
5

Publications

A Young Man with Accelerated Hyperthermia, Hypercapnia, and Profound Muscle Rigidity after Ingestion of a Weight Loss Agent.
Annals of the American Thoracic Society 2020 Mar;17;361-366 2020 Mar
Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service.
Emergency medicine journal : EMJ 2015 May;32;383-6 2015 May
Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill.
Emergency medicine journal : EMJ 2010 Feb;27;159-60 2010 Feb
Dinitrophenol in weight loss: the poison center and public health safety.
Veterinary and human toxicology 1986 Dec;28;574-5 1986 Dec

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