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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ofatumumab

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 06/06/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies.
Clinical reviews in allergy & immunology 2018 Jun;54;375-385 2018 Jun
Ofatumumab in combination with glucocorticoids for primary therapy of chronic graft-versus-host disease: phase I trial results.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2015 Jun;21;1074-82 2015 Jun
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.
The New England journal of medicine 2014 Jul 17;371;213-23 2014 Jul 17
U.S. Food and Drug Administration approval: ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Sep 01;16;4331-8 2010 Sep 01

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