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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Methylene chloride
2
XIV.c
Carboxyhemoglobinemia
2
Last update :
04/10/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Pulmonary toxicity following exposure to methylene chloride and its combustion product, phosgene.
Treatment of methylene chloride induced carbon monoxide poisoning with hyperbaric oxygenation.
Hyperbaric oxygen for methylene chloride poisoning: report on two cases.
Diffuse pulmonary injury following paint remover exposure.
Carbon monoxide poisoning secondary to inhaling methylene chloride.
Chronic carbon monoxide poisoning caused by methylene chloride paintstripper.
Elevated carbon monoxide levels from exposure to methylene chloride.