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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
V.ae
Pleural effusion, massive
Last update :
01/01/1970
Causative drugs
1
Bosutinib
I.a
I - Interstitial/parenchymal lung disease
I.a - Pneumonitis (ILD), acute and/or severe (may cause ARDS)
I.b
I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
I.ao
I - Interstitial/parenchymal lung disease
I.ao - Pulmonary infiltrates
V.a
V - Pleural and/or pericardial involvement
V.a - Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
V.ae
V - Pleural and/or pericardial involvement
V.ae - Pleural effusion, massive
VI.b
VI - Pulmonary vasculopathies
VI.b - Pulmonary arterial hypertension
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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