Pneumotox » Drug » Phenytoin (diphenylhydantoin) » IV.n - Obstructive airway dysfunction (see also IVc, XVx)

Phenytoin (diphenylhydantoin)

As a late outcome of phenytoin-induced Steven-Johnson syndrome (PMID 27222786)

Last update : 26/05/2016

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment