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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Anti-angiogenesis/-angiogenic agents
4
Last update :
22/11/2018
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ad
Osteonecrosis of the jaw
1
XI - Miscellaneous
XI.w
Cavitation/necrosis of lung tumor or metastases
2
XII - Cardiovascular involvement / toxicity
XII.ai
Cardiotoxicity
3
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Bevacizumab
Pazopanib
Sunitinib
