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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Ado-trastuzumab emtansine
2
Last update :
25/11/2024
I - Interstitial/parenchymal lung disease
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
1
I.e
Acute eosinophilic pneumonia (AEP)
1
II - Pulmonary edema - Acute lung injury - ARDS
II.f
Hypoxemia, low oxygen saturation (may occur in isolation)
1
II.v
Hypoxemia w/wo ARF from hepatopulmonary syndrome
1
VI - Pulmonary vasculopathies
VI.b
Pulmonary arterial hypertension
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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