Pneumotox » Drug » Dabigatran

Dabigatran

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Last update : 02/02/2014

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

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I.b Pneumonitis (ILD)

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I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

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III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

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III.c Hemoptysis

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III.h Major/massive hemoptysis

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V.n Hemopericardium - Bloody pericardial effusion

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XII.z Heart valve thrombosis

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XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

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XVI.j Imaging: Wandering (migratory) pulmonary opacities

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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