Pneumotox » Drug » Olanzapine

Olanzapine

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Last update : 09/08/2012

I.b Pneumonitis (ILD)

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V.b Eosinophilic pleural effusion

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V.m Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

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VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

1

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

1

X.a DRES syndrome - DRESS-like reaction

1

X.b Antiphospholipid antibodies w/wo the APL syndrome

1

XIX.d BAL: Gross or microscopic bleeding/hemorrhage

1

Diagnosing DIRD

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Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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