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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Thyroid hormones (exogenous)
1
And abuse thereof
Last update :
15/12/2018
II - Pulmonary edema - Acute lung injury - ARDS
II.d
Pulmonary edema, cardiogenic
1
VI - Pulmonary vasculopathies
VI.b
Pulmonary arterial hypertension
-
XI - Miscellaneous
XI.r
Death following exposure or poisoning
1
XII - Cardiovascular involvement / toxicity
XII.d
Myocarditis (can be fulminant)
1
XII.f
Cardiomyopathy (acute, subacute, chronic)
1
XII.al
Hyperkinetic circulation
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amiodarone
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
Weight loss-, slimming agents