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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Succinylcholine
1
Last update :
17/05/2013
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.a
Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)
1
IX.d
Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
1
IX.i
Respiratory arrest - Apnea
1
IX.k
Trismus (lockjaw)
1
XI - Miscellaneous
XI.r
Death following exposure or poisoning
1
XII - Cardiovascular involvement / toxicity
XII.n
Cardiovascular collapse - Cardiogenic shock - Hypotension
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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