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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Pembrolizumab
5
XVI.e
Imaging: Pulmonary opacities with a subpleural distribution
1
Last update :
05/10/2018
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Atezolizumab
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
Ipilimumab
Lambrolizumab
Nivolumab
PD-1/PD-L1-inhibitors or blocking agents/drugs
Publications
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.
Anti-PD-1 Inhibitor-Related Pneumonitis in Non-Small Cell Lung Cancer.