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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Superwarfarins (vitamin K super antagonist rodenticides)

4

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 05/12/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Brodifacoum
4
Bromadiolone
1
Difenacoum
1
Opiates - Opioids - Opium
5
Opioids (synthetic)
5
Rodenticides
4
Warfarin
5

Publications

Brodifacoum poisoning with toxicokinetic data.
Clinical toxicology (Philadelphia, Pa.) 2007;45;487-9 2007
Fatal brodifacoum rodenticide poisoning: autopsy and toxicologic findings.
Journal of forensic sciences 1999 Jul;44;851-5 1999 Jul
Diffuse alveolar hemorrhage secondary to superwarfarin ingestion.
Chest 1992 Oct;102;1301-2 1992 Oct

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