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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Efavirenz

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 09/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Highly active antiretroviral therapy - HAART
3

Publications

Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.
The Journal of infection 2006 Feb;52;e39-40 2006 Feb
Hypersensitivity syndrome associated with efavirenz therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000 Jan;30;227-8 2000 Jan

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