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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Highly active antiretroviral therapy - HAART

3
Last update : 27/09/2018
I - Interstitial/parenchymal lung disease

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1

I.m ILD with a granulomatous component

1
II - Pulmonary edema - Acute lung injury - ARDS

II.b ARDS - Acute lung injury

1
VII - Mediastinal involvement

VII.a Lymphadenopathy (intrathoracic)

1
X - Systemic/Distant conditions, syndromes and reactions

X.a DRES syndrome - DRESS-like reaction

1

X.i The immune reconstitution syndrome (IRCS)

3

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

1
XI - Miscellaneous

XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

1
XV - Pathology

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
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Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abacavir
2
Dolutegravir
1
Sofosbuvir
1

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