Pneumotox » Drug » Highly active antiretroviral therapy - HAART

Highly active antiretroviral therapy - HAART

3

Last update : 27/09/2018

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1

I.m ILD with a granulomatous component

1

II.b ARDS - Acute lung injury

1

VII.a Lymphadenopathy (intrathoracic)

1

X.a DRES syndrome - DRESS-like reaction

1

X.i The immune reconstitution syndrome (IRCS)

3

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

1

XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

1

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

More detailed checklist

See also under