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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Enalapril

3

VIII.a Angioedema (may cause UAO, asphyxia and death)

2
Last update : 09/05/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Angiotensin converting enzyme inhibitors (ACEI)
5

Publications

Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit.
The American journal of medicine 2015 Jul;128;785-9 2015 Jul
Images in clinical medicine. Angioedema.
The New England journal of medicine 2011 Jul 14;365;e4 2011 Jul 14
Enalapril-induced angioedema: a dental concern.
General dentistry 2011;59;148-50 2011
Angiotensin-converting enzyme inhibitors and angioedema.
Allergy, asthma & immunology research 2010 Jul;2;195-8 2010 Jul
Life-threatening angio-oedema and death associated with the ACE inhibitor enalapril.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2007 Apr;97;244-5 2007 Apr
Incidence and characteristics of angioedema associated with enalapril.
Archives of internal medicine 2005 Jul 25;165;1637-42 2005 Jul 25
Angio-oedema induced by enalapril.
Journal of internal medicine 1995 Aug;238;179-81 1995 Aug
[Angioedema caused by enalapril (Reniten)].
Schweizerische medizinische Wochenschrift 1989 Sep 16;119;1253-6 1989 Sep 16
Fatal angioedema associated with enalapril.
The Canadian journal of cardiology 1989 Oct;5;335-6 1989 Oct

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