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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Immunoglobulins, intravenous (IVIG)
3
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Anaphylaxis-Anaphylactoid reaction (can be fatal)
2
Last update :
23/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)
Publications
Adverse effects of human immunoglobulin therapy.
A new strategy for the prevention of IgA anaphylactic transfusion reactions.
[Anaphylactoid reactions to normal immunoglobulins].
Side-effects of intravenous immune globulins.
Common variable immunodeficiency: the disorder and treatment.