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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

I.b Pneumonitis (ILD)

2
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Pegylated-interferon induced interstitial pneumonitis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2014 Mar;24;219-20 2014 Mar
Decline in pulmonary function during chronic hepatitis C virus therapy with modified interferon alfa and ribavirin.
Journal of viral hepatitis 2013 Apr;20;e115-23 2013 Apr
Diagnosis and management of interstitial pneumonitis associated with interferon therapy for chronic hepatitis C.
World journal of gastroenterology 2010 Sep 21;16;4394-9 2010 Sep 21
Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature.
Digestive diseases and sciences 2010 Mar;55;579-85 2010 Mar
Interstitial pneumonitis associated with pegylated interferon alpha-2b therapy for chronic hepatitis C: case report.
Annals of hepatology 2008;7;87-90 2008
Interstitial pneumonitis in a patient with melanoma treated with the high dose interferon alpha 2b regimen.
The Israel Medical Association journal : IMAJ 2004 Oct;6;636-7 2004 Oct
Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis C.
The American journal of gastroenterology 2002 Sep;97;2432-40 2002 Sep
Interstitial pneumonitis in a patient treated with alpha-interferon and ribavirin for hepatitis C infection.
The American journal of the medical sciences 2001 Oct;322;233-5 2001 Oct
Interstitial pneumonia caused by interferon-alpha in chronic myelogenous leukemia.
American journal of hematology 1994 Nov;47;253 1994 Nov
Recombinant alpha interferon in retreatment of two patients with pulmonary lymphoma. Dramatic responses with resolution of pulmonary complications.
The American journal of medicine 1984 Aug;77;355-8 1984 Aug

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