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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Pegylated interferon
3

Publications

Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a.
Revista da Sociedade Brasileira de Medicina Tropical 2012 Oct;45;655-6 2012 Oct
Interstitial pneumonitis in a patient with chronic hepatitis C and chronic renal failure on interferon therapy.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2011 Jul;58;47-52 2011 Jul
Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature.
Digestive diseases and sciences 2010 Mar;55;579-85 2010 Mar
Bronchiolitis obliterans organizing pneumonia. Clinical and roentgenological features in 26 cases.
Respiration; international review of thoracic diseases 2005;72;254-62 2005
Fulminant bronchiolitis obliterans organizing pneumonia following 2 d of treatment with hydroxyurea, interferon-alpha and oral cytarabine ocfosfate for chronic myelogenous leukemia.
European journal of haematology 2004 Jul;73;67-70 2004 Jul
Significant pulmonary toxicity associated with interferon and ribavirin therapy for hepatitis C.
The American journal of gastroenterology 2002 Sep;97;2432-40 2002 Sep
Interferon-related bronchiolitis obliterans organizing pneumonia.
Chest 1994 Aug;106;612-3 1994 Aug

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