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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Interferon alpha/beta

3

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 23/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pegylated interferon
3

Publications

Simultaneous occurrence of pleural effusion and interstitial pneumonitis after treatment with pegylated interferon for hepatitis C virus infection.
Southern medical journal 2011 Feb;104;140-2 2011 Feb
Pleural effusion associated with pegylated interferon alpha and ribavirin treatment for chronic hepatitis C.
Journal of hospital medicine 2009 Sep;4;E45-6 2009 Sep
Fatality and interferon alpha for malignant melanoma.
Lancet (London, England) 1998 Oct 31;352;1443-4 1998 Oct 31

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